Comparison of PET-CT and magnetic resonance diffusion weighted imaging with body suppression (DWIBS) for initial staging of malignant lymphomas

详细信息    查看全文

• 作者：Velasco St¨¦phane ; Burg Samuel ; Delwail Vincent ; Guilhot Joelle ; Perdrisot Remy ; Guilhot Gaudeffroy Francois ; Tasu Jean-Pierre
• 关键词：Lymphoma ; Staging ; DWIBS ; FDG PET/CT
• 刊名：European Journal of Radiology
• 出版年：2013
• 出版时间：November, 2013
• 年：2013
• 卷：82
• 期：11
• 页码：2011-2017
• 全文大小：1161 K

文摘

Objective

To evaluate the clinical impact of diffusion-weighted whole-body imaging with background body signal suppression (DWIBS) in staging of malignant lymphoma.

Methods

Twenty-three patients with proven malignant lymphomas were prospectively enrolled. DWIBS (b = 0, 1000 s/mm²) examinations and PET-CT were performed respectively on an Intera 1.5 T unit and a Gyroscan PET-CT scan (Philips Medical system, Best, the Netherland). The criteria for positive node involvement were a size over 10 mm or an apparent diffusion coefficient (ADC) value under 0.75 10^?3 mm²/s for nodes under 10 mm. For extranodal analysis, a high or heterogeneous signal on DWIBS was considered as positive. In cases of discordance, the reference standard for each region or organ was established at 6 months after the diagnosis according to all available clinical, biological information, as well as histological evidence or follow-up to prove or disprove the presence of disease.

Results

DWIBS and PET-CT results were congruent in 333 node regions on the 345 areas analyzed, with excellent agreement (¦Ê = 0.97, P < 0.0001). From 433 organs analyzed (one patient had splenectomy) extranodal disease was detected in 22 organs on DWIBS. The two imaging techniques agreed on 430 organs (¦Ê = 0.99, P < 0.0001). Finally, Ann Arbor stages based on DWIBS and those of PET/CT were in agreement for 23 patients.

Conclusions

For malignant lymphoma in a pre-therapeutic context, agreement between diffusion-weighted whole-body imaging and PET/CT is high for Ann Arbor staging.