A Derived Allosteric Switch Underlies the Evolution of Conditional Cooperativity between HOXA11 and FOXO1
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- 作者：Mauris C. Nnamani1 ; 8 ; Soumya Ganguly2 ; 8 ; Eric M. Erkenbrack1 ; Vincent J. Lynch3 ; Laura S. Mizoue4 ; Yingchun Tong1 ; Heather L. Darling2 ; Monika Fuxreiter5 ; Jens Meiler2 ; jens.meiler@vanderbilt.edu" class="auth_mail" title="E-mail the corresponding author ; Gü ; nter P. Wagner1 ; 6 ; 7 ; gunter.wagner@yale.edu" class="auth_mail" title="E-mail the corresponding author
- 刊名：Cell Reports
- 出版年：2016
- 出版时间：7 June 2016
- 年：2016
- 卷：15
- 期：10
- 页码：2097-2108
- 全文大小：3945 K
文摘
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The HOXA11 protein has a regulatory motif that masks its activation domain
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In placental mammals, upon binding to FOXO1, HOXA11 unmasks its activation domain
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In the ancestral HOXA11, binding to FOXO1 does not unmask the activation domain
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In placental mammals the HOXA11::FOXO1 complex evolved a neo-allosteric switch