Re-assessing the mechanism of action of n 鈭?#xa0;3 PUFAs
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- 作者：Vincenzo Mollace ; Micaela Gliozzi ; Cristina Carresi ; Vincenzo Musolino ; Francesca Oppedisano
- 关键词：PUFA-3 ; Cardioprotection ; Free radicals ; Oxidative stress ; Lipoxidative processes ; 4-Hydroxyhexenal
- 刊名：International Journal of Cardiology
- 出版年：20 December, 2013
- 年：2013
- 卷：170
- 期：2_supp_S1
- 页码：S8-S11
- 全文大小：221 K
文摘
Recent evidence has been accumulated showing that use of dietary n 鈭?#xA0;3 polyunsaturated fatty acids (n 鈭?#xA0;3 PUFAs) produces significant benefits in counteracting many disease states, including coronary atherosclerosis, fatal arrhythmias and heart failure. Besides the mass of proposed pathophysiological mechanisms underlying the potential benefits of using n 鈭?#xA0;3 PUFAs, identification of clear molecular targets or an appropriate dosing strategy for these compounds still remain to be better elucidated. On the other hand, whilst n 鈭?#xA0;3 PUFAs have shown promise in all of these areas, results arising from clinical trials and 鈥榬eal-world鈥?evidence sometimes appear controversial. Here we report on recent advances in molecular targets identified for better assessment of the mode of action of these interesting compounds. In addition, some appealing hypotheses of their antioxidant properties will be discussed for better characterisation of their mode of action and potential use in health and disease.