Activation of PPAR-γ reduces HPA axis activity in diabetic rats by up-regulating PI3K expression
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- 作者：Rafael Carvalho Torres rafaelctorres@hotmail.com" class="auth_mail" title="E-mail the corresponding author ; Nathalia Santos Magalhã ; es magalhaess.nathalia@gmail.com" class="auth_mail" title="E-mail the corresponding author ; Patrí ; cia M.R. e Silva patmar@ioc.fiocruz.br" class="auth_mail" title="E-mail the corresponding author ; Marco A. Martins mmartins@ioc.fiocruz.br" class="auth_mail" title="E-mail the corresponding author ; Vinicius F. Carvalho ; vfrias@ioc.fiocruz.br" class="auth_mail" title="E-mail the corresponding author
- 关键词：Diabetes ; Glucocorticoids ; HPA axis ; PPAR-γ ; PI3K
- 刊名：Experimental and Molecular Pathology
- 出版年：2016
- 出版时间：October 2016
- 年：2016
- 卷：101
- 期：2
- 页码：290-301
- 全文大小：3468 K
文摘
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Activation of PPAR-γ decreases plasma corticosterone levels in diabetic rats.
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Activation of PPAR-γ reduces corticotroph cells hyperplasia and plasma ACTH levels in diabetic rats.
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Activation of PPAR-γ increases PI3K expression in the HPA axis of diabetic rats.
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Wortmannin impaired rosiglitazone mediated down regulation of corticosterone levels.