The capsular polysaccharide and lipopolysaccharide structures of two carbapenem resistant Klebsiella pneumoniae outbreak isolates

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• 作者：Joanna Kubler-Kielb^a ; ^{kielbj@mail.nih.gov} ; Evgeny Vinogradov^b ; Weng-Ian Ng^a ; Beata Maczynska^c ; Adam Junka^c ; Marzenna Bartoszewicz^c ; Adrian Zelazny^d ; John Bennett^e ; Rachel Schneerson^a ; ^&dagger ;
• 关键词：CRKP ; carbapenem resistant Klebsiella pneumoniae ; KPC ; K. pneumoniae carbapenemase ; CPS ; capsular polysaccharide ; LPS ; lipopolysaccharide ; NOE ; nuclear Overhauser effect ; gCOSY ; gradient correlation spectroscopy ; NOESY ; nuclear Overhauser effect spectrosc
• 刊名：Carbohydrate Research
• 出版年：2013
• 出版时间：22 March, 2013
• 年：2013
• 卷：369
• 期：Complete
• 页码：6-9
• 全文大小：362 K

文摘

Carbapenem resistant Klebsiella pneumoniae (CRKP) are isolated with increasing frequency, especially from immunocompromized patients. The capsular polysaccharide (CPS) types of CPKP were not determined. Investigation of two CRKP isolates from a 2011 outbreak at the Clinical Center, the National Institutes of Health, identified a new capsular type shared by the two isolates, similar to K. pneumonia K19 and K34 but structurally different than any published K. pneumoniae CPS repeating unit: