Germinal Center Lymphocyte Ratios and Successful HIV Vaccines

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• 作者：Paula Gonzalez-Figueroa¹ ; Jonathan A. Roco¹ ; Carola G. Vinuesa¹ ; ^{carola.vinuesa@anu.edu.au}
• 刊名：Trends in Molecular Medicine
• 出版年：2017
• 出版时间：February 2017
• 年：2017
• 卷：23
• 期：2
• 页码：95-97
• 全文大小：477 K
• 卷排序：23

文摘

Current HIV vaccines are poor inducers of neutralizing antibodies (nAbs). A recent study in Cell Reports used serial fine-needle aspirates from rhesus macaque lymph nodes following HIV-1 surface envelope glycoprotein (Env) trimer immunization, generating a substantial production of HIV-1 nAbs. A remarkable correlation was found between antibody titers and a high frequency and ratio of germinal center B and T follicular helper (TFH) lymphocytes.