Synthesis of antimicrotubule dibenzoxepines
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- 作者：Virginie Colombel ; Agnè ; s Joncour ; Sylviane Thoret ; Joë ; lle Dubois ; Jé ; rô ; me Bignon ; Joanna Wdzieczak-Bakala ; Olivier Baudoin
- 关键词：Biaryls ; Tubulin ; Cytotoxic agents
- 刊名：Tetrahedron Letters
- 出版年：2010
- 出版时间：9 June 2010
- 年：2010
- 卷：51
- 期：23
- 页码：3127-3129
- 全文大小：286 K
文摘
New dibenzoxepines 5a–i bearing various substituents on B- and C-rings were synthesized in a straightforward manner using a Suzuki–Miyaura coupling, a Grignard addition, and a cyclodehydration as key steps. The antimicrotubule activity of all analogues was evaluated and compared to reference compounds. Compounds 5d–f displayed the highest activity for this type of allocolchicinoids to date.