Comparison of three quantitative HCV RNA assays in samples from HCV genotype 1- or 4-infected patients treated with the NS3/4A protease inhibitor simeprevir
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- 作者：Bart Feverya ; bfevery@its.jnj.com" class="auth_mail" title="E-mail the corresponding author ; Simone Susserb ; susser@med.uni-frankfurt.de" class="auth_mail" title="E-mail the corresponding author ; Oliver Lenza ; olenz@its.jnj.com" class="auth_mail" title="E-mail the corresponding author ; Gavin Clohertyc ; gavin.cloherty@abbott.com" class="auth_mail" title="E-mail the corresponding author ; Dany Pernerb ; perner@med.uni-frankfurt.de" class="auth_mail" title="E-mail the corresponding author ; Leen Gillesa ; LGILLES@its.jnj.com" class="auth_mail" title="E-mail the corresponding author ; Patrick De Lochta ; PDLOCHT1@its.jnj.com" class="auth_mail" title="E-mail the corresponding author ; Gaston Picchiod ; GPicchio@its.jnj.com" class="auth_mail" title="E-mail the corresponding author ; Sandra De Meyera ; SDMEYER@its.jnj.com" class="auth_mail" title="E-mail the corresponding author ; Christoph Sarrazinb ; sarrazin@em.uni-frankfurt.de" class="auth_mail" title="E-mail the corresponding author
- 关键词：ART ; Abbott RealTime HCV ; CAP ; Roche AmpliPrep COBAS® ; TaqMan® ; HCV v2.0 ; DAA ; direct-acting antiviral agent ; GT ; genotype ; HCV ; hepatitis C virus ; HPS ; Roche High-Pure-System COBAS® ; TaqMan® ; HCV v2.0 ; LLOQ ; lower limit of quantification ; LOD ; limit of detection ; PegIFN ; pegylated interferon-α ; RBV ; ribavirin ; RVR ; rapid virological response ; SVR ; sustained virologic response ; SVR12 ; SVR 12 weeks after end of treatment ; TD ; target detected ; TND ; target not detected
- 刊名：Journal of Clinical Virology
- 出版年：2015
- 出版时间：November 2015
- 年：2015
- 卷：72
- 期：Complete
- 页码：133-140
- 全文大小：1673 K
文摘
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Differences between HCV RNA assays might influence treatment decisions.
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Concordance of 3 real-time PCR-based HCV RNA assays was tested.
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Plasma samples from Phase III simeprevir/PegIFN/RBV studies (HCV genotype 1 and 4) were used.
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Inter-assay concordance was generally good, except in low viremic samples at early time points.
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An HCV RNA threshold <25 IU/mL was more assay-independent than RNA undetectability.