Effect of interleukin-10 gene promoter polymorphisms -1082 G/A and -592 C/A on response to therapy in children and adolescents with chronic hepatitis C virus infection

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• 作者：Hanaa M. El-Karaksy^a ; ^{hanaakaraksy@kasralainy.edu.eg} ; Sahar A. Sharaf^b ; Iman A. Mandour^b ; Engy A. Mogahed^a ; Normeen H. Rady^b ; Fatma A. El- Mougy^b
• 关键词：HCV ; hepatitis C virus ; Th1 ; Type 1 helper T cells ; Th2 ; Type 2 helper T cells ; IL ; interleukin ; SNPs ; single nucleotide polymorphisms ; PEG-IFN ; pegylated interferon ; AST ; aspartate amino transferase ; ALT ; alanine amino transferase ; GGT ; gamma-glutamyl transferase ; AP ; alkaline phosphatase ; PCR ; polymerase chain reaction ; EVR ; early virologic response ; ETR ; end of treatment response ; SVR ; sustained virological response ; SDS ; Sequence Detection System ; IQR ; interquartile range ; HAI ; histological
• 刊名：Human Immunology
• 出版年：2016
• 出版时间：December 2016
• 年：2016
• 卷：77
• 期：12
• 页码：1248-1253
• 全文大小：751 K
• 卷排序：77

文摘

Studying predictors of response to therapy for hepatitis C virus (HCV) infection in children may help avoid the inappropriate use of currently available costly therapy associated with numerous adverse effects. We tested the hypothesis that inheritance of single nucleotide polymorphisms (SNPs) of the interleukin-10 (IL-10) promoter gene might influence response to HCV treatment.Patients and methodsThe impact of SNPs, -1082 G/A and -592 C/A, in the promoter region of IL-10 gene, on response to HCV therapy was assessed in a cohort of 40 children treated with a combination of pegylated interferon (Peg-IFN) α2b and ribavirin.ResultsSustained virological response was achieved in 48.7%. High viral load was associated with non-response to therapy. There was no association between histopathological degree of inflammation or fibrosis and response to therapy. There was no direct statistically significant association between polymorphisms in the IL-10 gene (-1082G/A and -592 C/A) as regards inflammation or response to therapy in children. As for the SNP -592 C/A; there was a statistically significant association with the score of fibrosis (P < 0.004), concluding that the A allele was protective from moderate and severe fibrosis. Meanwhile the SNP -1082G/A did not show any association with the fibrosis score.ConclusionWe could not associate response to therapy for HCV with IL-10 polymorphisms -1082 G/A and -592 C/A. For the SNP -592 C/A, the A allele protected from moderate and severe fibrosis.