Comparative evaluation of aggressiveness traits in staphylococcal strains from severe infections versus nasopharyngeal carriage

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• 作者：Oana Săndulescu^a ; ^b ; ¹ ; Coralia Bleotu^c ; ^d ; ¹ ; Lilia Matei^c ; Anca Streinu-Cercel^a ; ^b ; ^{anca_sc@yahoo.com} ; Mihaela Oprea^e ; Elena Carmina Drăgulescu^e ; Mariana Carmen Chifiriuc^d ; ^f ; Alexandru Rafila^a ; ^b ; Daniel Pirici^g ; Daniela Tălăpan^a ; ^b ; Olga Mihaela Dorobăţ^b ; Alina Cristina Neguţ^a ; ^b ; Dan Oţelea^b ; Ioana Berciu^a ; ^b ; Daniela Adriana Ion^a ; ^h ; Irina Codiţă^e ; Petre Iacob Calistru^a ; Adrian Streinu-Cercel^a ; ^b
• 关键词：Adhesion ; Biofilm ; Invasion ; S. aureus ; Soluble virulence factors
• 刊名：Microbial Pathogenesis
• 出版年：2017
• 出版时间：January 2017
• 年：2017
• 卷：102
• 期：Complete
• 页码：45-53
• 全文大小：1444 K
• 卷排序：102

文摘

The staphylococcal aggressiveness score (SAS) assesses tetrad morphology, aggregative adhesion and methicillin resistance. The score discriminates between biofilm-related relapse-prone (score 0 or 1) and acute fulminant infections (score 2 or 3). Staphylococci infecting immunocompetent patients direct their energy reserve towards producing soluble virulence factors. Staphylococci infecting immunocompromised patients downregulate virulence expression while displaying increased fitness. Cluster adhesion, a novel bacterial trait, correlates with staphylococcal adhesion and invasion.