Identification of Zika Virus and Dengue Virus Dependency Factors using Functional Genomics
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- 作者：George Savidis1 ; 5 ; William M. McDougall1 ; 5 ; Paul Meraner1 ; 5 ; Jill M. Perreira1 ; Jocelyn M. Portmann1 ; Gaia Trincucci1 ; Sinu P. John2 ; Aaron M. Aker1 ; Nicholas Renzette1 ; Douglas R. Robbins1 ; Zhiru Guo3 ; Sharone Green3 ; Timothy F. Kowalik1 ; Abraham L. Brass1 ; 4 ; abraham.brass@umassmed.edu" class="auth_mail" title="E-mail the corresponding author
- 关键词：Zika virus ; dengue virus ; yellow fever virus ; flavivirus ; arbovirus ; EMC ; AXL ; CRISPR/Cas9 screen ; MORR ; RNAi screen
- 刊名：Cell Reports
- 出版年：2016
- 出版时间：28 June 2016
- 年：2016
- 卷：16
- 期：1
- 页码：232-246
- 全文大小：6940 K
文摘
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RNAi and CRISPR/Cas9 screens were used to find flavivirus dependencies
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The screens recovered host factors involved in endocytosis and heparin sulfation
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The EMC is required by DENV and ZIKV in the early stages of replication
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These studies give a systems-wide view of human-flavivirus interactions