Reference intervals for whole blood viscosity using the analytical performance-evaluated scanning capillary tube viscometer

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• 作者：J.M. Jung^a ; ¹ ; D.H. Lee^b ; ^c ; ¹ ; K.T. Kim^c ; M.S. Choi^d ; Y.G. Cho^d ; H.S. Lee^d ; S.I. Choi^d ; S.R. Lee^e ; ^{medorche@jbnu.ac.kr" class="auth_mail} ; D.S. Kim^d ; ^{dskim@jbnu.ac.kr" class="auth_mail}
• 关键词：Whole blood viscosity ; Reference intervals ; Scanning capillary tube viscometer ; Hematocrit
• 刊名：Clinical Biochemistry
• 出版年：April, 2014
• 年：2014
• 卷：47
• 期：6
• 页码：489-493
• 全文大小：283 K

文摘

Objectives

This study was performed to establish the reference intervals for whole blood viscosity (WBV) using the analytical performance-evaluated scanning capillary tube viscometer (SCTV).

Design and methods

The analytical performance of the SCTV was evaluated using three different levels of QC materials and sixty human EDTA-blood samples. To establish the reference intervals for WBV, 297 healthy individuals (123 men and 174 women) were selected from 1083 subjects.

Results

Within-day precisions with QC materials and human whole blood and between-day precisions with QC materials were below 5.0%, 6.6% and 8.0% in CVs at all shear rates, respectively. Comparison tests between the SCTV and the Brookfield viscometer showed a significant correlation (R² = 0.972, p < 0.001). The reference intervals for WBV in healthy men were 3.66-5.41 cP at 300 s^鈭?#xA0;1 and 23.15-36.45 cP at 1 s^鈭?#xA0;1 while those in women were 3.27-4.32 cP at 300 s^鈭?#xA0;1 and 18.20-27.36 cP at 1 s^鈭?#xA0;1, respectively.

Conclusions

Using the analytical performance-evaluated SCTV, the reference intervals for WBV were established in healthy adults, which could be beneficial to the clinical utility of WBV in the aspect of appropriate modalities for the improvement of blood viscosity.