An update on the etiology and diagnostic evaluation of a leukemoid reaction

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• 作者：Vissaria Sakka ; Sotirios Tsiodras ; Evangelos J. Giamarellos-Bourboulis and Helen Giamarellou
• 关键词：Leukemoid reaction ; Diagnosis ; Chronic myelogenous leukemia ; Chronic neutrophilic leukemia ; Malignancy
• 刊名：European Journal of Internal Medicine
• 出版年：2006
• 出版时间：October 2006
• 年：2006
• 卷：17
• 期：6
• 页码：394-398
• 全文大小：116 K

文摘

Persistent neutrophilic leukocytosis above 50,000 cells/μL when the cause is other than leukemia defines a leukemoid reaction. The diagnostic work-up consists of the exclusion of chronic myelogenous leukemia (CML) and chronic neutrophilic leukemia (CNL) and the detection of an underlying cause. The major causes of leukemoid reactions are severe infections, intoxications, malignancies, severe hemorrhage, or acute hemolysis. The present article points out the difficulties in the differential diagnosis of a leukemoid reaction and suggests an algorithm for a rational clinical and laboratory evaluation of this problematic entity.