Duration of wheezy episodes in early childhood is independent of the microbial trigger

详细信息    查看全文

• 作者：Christian J. Carlsson ; MD^a ; Nadja H. Vissing ; MD ; PhD^a ; Astrid Sevelsted ; MSc^a ; Sebastian L. Johnston ; FRCP ; PhD^b ; Klaus B&oslash ; nnelykke ; MD ; PhD^a ; Hans Bisgaard ; MD ; DMSc^a ; ^{bisgaard@copsac.com" class="auth_mail" title="E-mail the corresponding author}
• 关键词：Respiratory tract infections ; wheezy episodes ; pediatrics
• 刊名：Journal of Allergy and Clinical Immunology
• 出版年：2015
• 出版时间：November 2015
• 年：2015
• 卷：136
• 期：5
• 页码：1208-1214.e5
• 全文大小：592 K

文摘

Wheezy episodes in young children are often triggered by viral and bacterial respiratory tract infections, but there is little evidence supporting the hypothesis that symptom duration depends on the specific microbial trigger.

<h4 id="absSec_2">Objectiveh4>

We sought to investigate whether the duration of wheezy episodes in young children depends on the microbial trigger.

<h4 id="absSec_3">Methodsh4>

Two hundred eighty-three children from the Copenhagen Prospective Study on Asthma in Childhood₂₀₀₀ at-risk birth cohort were prospectively examined for common airway pathogenic bacteria and viruses during acute wheezy episodes in the first 3 years of life. Findings were related to symptomatic duration of episodes, as monitored in daily diary cards from birth.

<h4 id="absSec_4">Resultsh4>

Eight hundred thirty-seven samples were investigated for viruses, bacteria, or both. Both viruses and bacteria were identified in 55% of episodes, bacteria were identified exclusively in 31% of episodes, and viruses were identified exclusively in 10% of episodes. The median duration of acute symptoms was 9 days (interquartile range, 5-16 days), and duration was independent of bacterial or viral species.

<h4 id="absSec_5">Conclusionsh4>

The duration of wheezy episodes was independent of pathogenic airway bacterial or viral species. This suggests that symptom burden from infections is dependent on other factors, such as environmental exposures or host factors. The common term viral wheeze seems inappropriate in view of the finding of pathogenic bacteria in 86% of wheezy episodes.