RNA-sequencing study of peripheral blood monocytes in chronic periodontitis
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- 作者：Yao-Zhong Liua ; yliu8@tulane.edu" class="auth_mail" title="E-mail the corresponding author ; Pooja Maneyb ; pmaney@lsuhsc.edu" class="auth_mail" title="E-mail the corresponding author ; Jyoti Purib ; Yu Zhoua ; Melody Baddooc ; Michael Strongc ; Yu-Ping Wangd ; Erik Flemingtonc ; Hong-Wen Denga
- 关键词：CP ; chronic periodontitis ; RNA-seq ; RNA-sequencing ; PBMs ; peripheral blood monocytes ; DEx ; differentially expressed ; DAVID ; Database for Annotation ; Visualization and Integrated Discovery ; PPEE ; posterior probability of equal expression ; PPDE ; posterior probability of differential expression ; DCs ; dendritic cells ; Th ; T-helper ; LSUHSC ; Louisiana State University Health Science Center ; LSUHSC SOD ; LSUHSC School of Dentistry ; AA ; African American ; CAL ; clinical attachment loss ; PBMCs ; peripheral b
- 刊名：Gene
- 出版年：2016
- 出版时间：1 May 2016
- 年：2016
- 卷：581
- 期：2
- 页码：152-160
- 全文大小：316 K
文摘
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The functions of monocytes in periodontitis were first explored with RNA-seq.
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There was pervasive up-regulation of transcripts at isoform level in periodontitis.
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Novel signatures: FACR & CUX1 genes, endocytosis, cytokine production & apoptosis