Performance of simultaneous high temporal resolution quantitative perfusion imaging of bladder tumors and conventional multi-phase urography using a novel free-breathing continuously acquired radial compressed-sensing MRI sequence

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• 作者：Nainesh Parikh ; ^{nainesh.parikh@nyumc.org" class="auth_mail" title="E-mail the corresponding author} ; Justin M. Ream ^{Justin.Ream@nyumc.org" class="auth_mail" title="E-mail the corresponding author} ; Hoi Cheung Zhang ^{HoiCheung.Zhang@nyumc.org" class="auth_mail" title="E-mail the corresponding author} ; Kai Tobias Block ^{KaiTobias.Block@nyumc.org" class="auth_mail" title="E-mail the corresponding author} ; Hersh Chandarana ^{Hersh.Chandarana@nyumc.org" class="auth_mail" title="E-mail the corresponding author} ; Andrew B. Rosenkrantz ^{Andrew.Rosenkrantz@nyumc.org" class="auth_mail" title="E-mail the corresponding author}
• 关键词：MRI techniques ; MR urography ; Novel techniques ; Bladder cancer
• 刊名：Magnetic Resonance Imaging
• 出版年：2016
• 出版时间：June 2016
• 年：2016
• 卷：34
• 期：5
• 页码：694-698
• 全文大小：462 K

文摘

To investigate the feasibility of high temporal resolution quantitative perfusion imaging of bladder tumors performed simultaneously with conventional multi-phase MR urography (MRU) using a novel free-breathing continuously acquired radial MRI sequence with compressed-sensing reconstruction.

Methods

22 patients with bladder lesions underwent MRU using GRASP (Golden-angle RAdial Sparse Parallel) acquisition. Multi-phase contrast-enhanced abdominopelvic GRASP was performed during free-breathing (1.4 × 1.4 × 3.0 mm³ voxel size; 3:44 min acquisition). Two dynamic datasets were retrospectively reconstructed by combining different numbers of sequentially acquired spokes into each dynamic frame: 110 spokes per frame for 25-s temporal resolution (serving as conventional MRU for clinical interpretation) and 8 spokes per frame for 1.7-s resolution. Using 1.7-s resolution images, ROIs were placed within bladder lesions and normal bladder wall, a femoral artery arterial input function was generated, and the Generalized Kinetic Model was applied.

Results

Biopsy/cystectomy demonstrated 16 bladder tumors (13 stage ≥ T2, 3 stage ≤ T1) and 6 benign lesions. All lesions were well visualized using 25-s clinical multi-phase images. Using 1.7-s resolution images, K^trans was significantly higher in tumors (0.38 ± 0.24) than normal bladder (0.12 ± 0.02 = 8, p < 0.001) or benign lesions (0.15 ± 0.04, p = 0.033). Ratio between K^trans of lesions and normal bladder was nearly double for tumors than benign lesions (4.3 ± 3.4 vs. 2.2 ± 1.6), and K^trans was nearly double in stage ≥ T2 than stage ≤ T1 tumors (0.44 ± 0.24 vs. 0.24 ± 0.24), although these did not approach significance (p = 0.180–0.209), possibly related to small sample size.

Conclusion

GRASP allows simultaneous quantitative high temporal resolution perfusion of bladder lesions during clinical MRU examinations using only one contrast injection and without additional scan time.