Coordinated augmentation of NFAT and NOD signaling mediates proliferative VSMC phenotype switch under hyperinsulinemia
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- 作者：Abhijit Shiny ; shinyabhijit@gmail.com" class="auth_mail" title="E-mail the corresponding author ; drshiny@mdrf.in" class="auth_mail" title="E-mail the corresponding author ; Bhaskaran Regin ; Viswanathan Mohan ; Muthuswamy Balasubramanyam
- 关键词：Atherosclerosis ; Diabetes ; Vascular smooth muscle cells ; NFAT ; Innate immunity
- 刊名：Atherosclerosis
- 出版年：2016
- 出版时间：March 2016
- 年：2016
- 卷：246
- 期：Complete
- 页码：257-266
- 全文大小：2686 K
文摘
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Atherosclerosis is characterized by endothelial dysfunction, smooth muscle cell proliferation and inflammation.
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Our study shows the role of transcription factor, NFATc1 in hyperinsulinemia induced proliferation and migration of VSMCs.
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This study advocates the coordinated augmentation of NFATc1 and NOD signaling in the proliferation and migration of VSMCs.
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In patients with type 2 diabetes, expression of NFATc1 and NOD1/2 showed positive correlation with insulin resistance.