Recent developments in l-asparaginase discovery and its potential as anticancer agent
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- 作者：Abhinav Shrivastavaa ; 1Author Vitae ; Abdul Arif Khana ; b ; 1 ; abdularifkhan@gmail.com" class="auth_mail" title="E-mail the corresponding authorAuthor Vitae ; Mohsin Khurshidb ; cAuthor Vitae ; Mohd Abul KalambAuthor Vitae ; Sudhir K. JaindAuthor Vitae ; Pradeep K. SinghaleAuthor Vitae
- 关键词：l-Asparaginase ; Acute lymphoblastic leukaemia ; Anticancer ; l-Asparagine ; Erwinase ; Kidrolase ; PEG-asparaginase
- 刊名：Critical Reviews in Oncology and Hematology
- 出版年：2016
- 出版时间：April 2016
- 年：2016
- 卷：100
- 期：Complete
- 页码：1-10
- 全文大小：1099 K
文摘
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l-Asparaginase kills asparagine dependent leukaemia cells by hydrolysing asparagine.
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Bacterial l-asparaginase is used for treatment of leukaemia and other blood cancer.
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Bacterial l-asparaginase is associated with several adverse reactions.
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These adverse reactions necessitate development of l-asparaginase from other sources.