Identification of novel proliferative diabetic retinopathy related genes on protein-protein interaction network
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- 作者：Jian Zhang<sup>asup><sup> ; sup><sup>bsup><sup> ; sup><sup>1sup><sup> ; sup><sup>natalieeilatan@126.com" class="auth_mail" title="E-mail the corresponding authorsup>Author Vitae ; Jing Yang<sup>csup><sup> ; sup><sup>1sup><sup> ; sup><sup>mercuryyangjing@sina.com" class="auth_mail" title="E-mail the corresponding authorsup>Author Vitae ; Tao Huang<sup>csup><sup> ; sup><sup>tohuangtao@126.com" class="auth_mail" title="E-mail the corresponding authorsup>Author Vitae ; Yang Shu<sup>dsup><sup> ; sup><sup>shuyang1986@gmail.com" class="auth_mail" title="E-mail the corresponding authorsup>Author Vitae ; Lei Chen<sup>esup><sup> ; sup><sup>chen_lei1@163.com" class="auth_mail" title="E-mail the corresponding authorsup>Author Vitae
- 关键词：Proliferative diabetic retinopathy ; Shortest path approach ; Protein&ndash ; protein interaction
- 刊名：Neurocomputing
- 出版年：2016
- 出版时间：12 December 2016
- 年：2016
- 卷：217
- 期：Complete
- 页码：63-72
- 全文大小：683 K
文摘
Proliferative diabetic retinopathy (PDR) is an eye disease caused by diabetes. Because this disease may lead to blindness, effective treatments are urgently needed. However, the pathogenesis is far from good understanding, resulting in difficulties in designing effective treatments. In this study, we tried to give a few contributions to uncover its pathogenesis by searching for novel PDR-related genes. New genes were identified based on known genes related to proliferative diabetic retinopathy using a protein–protein interaction network with a shortest path approach. The newly identified genes were further filtered using a permutation test. The analyses showed that the discovered genes were highly enriched in gene ontology terms and KEGG pathways shared by known proliferative diabetic retinopathy related genes. Finally, we discussed the likelihood of some newly discovered genes being novel genes related to proliferative diabetic retinopathy.