Current topics in HIV pathogenesis, part 2: Inflammation drives a Warburg-like effect on the metabolism of HIV-infected subjects
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- 作者：Mouna AounallahaAuthor Vitae ; Xavier Dagenais-LussieraAuthor Vitae ; Mohamed El-FarbAuthor Vitae ; Vikram MehrajcAuthor Vitae ; Mohammad-Ali JenabiandAuthor Vitae ; Jean-Pierre RoutycAuthor Vitae ; Julien van Grevenynghea ; julien.vangrevenynghe@iaf.inrs.ca" class="auth_mail" title="E-mail the corresponding authorAuthor Vitae
- 关键词：HIV-1 ; Inflammation ; Metabolism ; Inflammasome ; Innate immunity
- 刊名：Cytokine & Growth Factor Reviews
- 出版年：2016
- 出版时间：April 2016
- 年：2016
- 卷：28
- 期：Complete
- 页码：1-10
- 全文大小：2449 K
文摘
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Inflammation, inflammasome and innate immunity plays a key role in stimulating metabolism, and vice versa.
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HIV-1 infection is characterized by the activation of NLRP3-inflammasome and elevated inflammation that are fuelled by bacterial translocation and dysbiosis.
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Inflammation and excessive metabolism during HIV-1 infection are not restored by ART.
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Inflammation-related deregulation of metabolism in HIV-1-infected subjects results in a number of heath complications.