Tissue responsiveness to estradiol and genistein in the sea bass liver and scale
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- 作者：Patrí ; cia I.S. Pintoa ; 1 ; ppinto@ualg.pt" class="auth_mail" title="E-mail the corresponding author ; M. Dulce Estê ; vã ; oa ; b ; 1 ; André ; Andradea ; Soraia Santosa ; Deborah M. Powera
- 关键词：ALP ; alkaline phosphatase ; E2 ; estradiol ; ESRs ; nuclear estrogen receptors ; ESR1 ; estrogen receptor 1 ; ESR2a ; estrogen receptor 2a ; ESR2b ; estrogen receptor 2b ; Gen ; genistein ; GPER ; G-protein-coupled estrogen receptor ; GPER-like ; G-protein-coupled estrogen receptor-like ; OSB ; osteoblasts ; OSC ; osteoclasts ; pNP ; para-nitrophenol ; pNPP ; para-nitrophenyl-phosphate ; PTHrP ; parathyroid hormone-related protein ; TRAP ; tartarate-resistant acid phosphatase ; Vtg ; vitellogenin
- 刊名：Journal of Steroid Biochemistry and Molecular Biology
- 出版年：2016
- 出版时间：April 2016
- 年：2016
- 卷：158
- 期：Complete
- 页码：127-137
- 全文大小：1872 K
文摘
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E2 and Gen increased plasma vitellogenin and E2 increased plasma mineral levels.
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TRAP and ALP activities and transcript expression was modified by E2 and Gen.
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Scales and liver express a different repertoire of nuclear/membrane estrogen receptors.
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E2 and Gen induced similar gene expression changes in scales and in liver.
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Regulation of E2 receptors and responsive gene expression was tissue-specific.