The replacement of the 2-methoxy substituent of N-((6,6-diphenyl-1,4-dioxan-2-yl)methyl)-2-(2-methoxyphenoxy)ethan-1-amine improves the selectivity for 5-HT1A receptor over α1-adrenoceptor and D2-like receptor subtypes
文摘
A potent 5-HT1A agonist selective over α1-ARs and D2-like receptors is discovered. It significantly reduces anxiety-linked behaviors in the light/dark paradigm. Docking analysis supports the structure-activity relationship studies. Correlative studies involves the generation of reliable predictive models.