- 作者：Paolo Pr ; oni ; Raffaele Pesavento ; Henrik T. Sø ; rensen ; Nicola Gennaro ; Fabio Dalla Valle ; Isabella Minotto ; Fabio Perina ; Vittorio Pengo ; Antonio Pagnan
- 关键词：Pulmonary embolism ; Deep venous thrombosis ; Cardiomyopathy ; Heart failure ; Coronary heart disease ; Atrial fibrillation
- 刊名：European Journal of Internal Medicine
- 出版年：2009
- 出版时间：September 2009
- 年：2009
- 卷：20
- 期：5
- 页码：470-473
- 全文大小：139 K
BackgroundIn up to 80 % of patients with pulmonary embolism (PE) no peripheral symptomatic thrombosis can be identified. Whether the heart may represent a source of PE is unknown.Methods
We conducted a cross-sectional survey of patients who were 60 years or older and were discharged from the hospitals of Veneto region, Italy between 2000 and 2006 with the diagnosis of PE. We compared the prevalence of several acute and chronic heart diseases in patients discharged with the diagnosis of PE alone with that of patients with co-occurring symptomatic peripheral deep venous thrombosis (PE/DVT).
Results
Out of 11,236 eligible patients, 9079 (81 % ) were discharged with the diagnosis of PE alone, and 2157 with that of PE/DVT. 3239 of the 9079 (35.7 % ) patients with isolated PE, and 666 of the 2157 (30.9 % ) with PE/DVT had at least one heart disease. The adjusted odds ratio (OR) for having at least one heart disease in patients with isolated PE as compared to those with PE/DVT was 1.26 (95 % CI, 1.13–1.40). The heart diseases that significantly contributed to the study results were all-cause cardiomyopathies (adjusted OR, 2.31; 95 % CI, 1.37–3.89), all-cause heart failure (1.82; 1.45–2.27), coronary heart disease (1.28; 1.08–1.52), and atrial fibrillation or flutter (1.28; 1.08–1.51).
Conclusions
There is an association between isolated PE and a number of heart diseases. The results of our survey generate the hypothesis that in older patients several heart diseases may directly account for the development of PE. Prospective studies are needed to confirm this hypothesis.