Evaluation of intestinal mucosal permeability function in patients with acute pancreatitis

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• 作者：Kamal Nagpal ; Vivek Ratna Minocha ; Vivek Agrawal and Suman Kapur
• 关键词：Gut permeability ; Acute pancreatitis
• 刊名：The American Journal of Surgery
• 出版年：2006
• 出版时间：July 2006
• 年：2006
• 卷：192
• 期：1
• 页码：24-28
• 全文大小：217 K

文摘

This study aims to evaluate the intestinal mucosal permeability in patients with acute pancreatitis. The lactulose:mannitol (L:M) ratio was used to assess permeability. It is an inexpensive and quite reliable method. The intestinal permeability was increased in patients with acute pancreatitis compared with the controls. In addition, patients with severe pancreatitis had higher intestinal barrier dysfunction compared with patients with mild pancreatitis, the L:M ratio being .2 and .029, respectively. It was also concluded that the permeability increased gradually over the course of pancreatitis and was maximum at day 7 (P < .01). This provides a window of opportunity for therapeutic intervention to prevent the late observed increase in intestinal permeability.