Inhibition of WAVE Regulatory Complex Activation by a Bacterial Virulence Effector Counteracts Pathogen Phagocytosis
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- 作者：Daniel Humphreys1 ; d.humphreys@sheffield.ac.uk" class="auth_mail" title="E-mail the corresponding author ; Vikash Singh1 ; Vassilis Koronakis1 ; 2 ; vk103@cam.ac.uk" class="auth_mail" title="E-mail the corresponding author
- 关键词：SCAR complex ; Rho GTPase ; virulence effector ; type 3 secretion system ; ADP-ribosylation factor
- 刊名：Cell Reports
- 出版年：2016
- 出版时间：11 October 2016
- 年：2016
- 卷：17
- 期：3
- 页码：697-707
- 全文大小：4100 K
文摘
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WAVE regulatory complex (WRC) and Arf and Rac1 direct phagocytosis of EPEC and EHEC
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Virulence effector EspG inhibits the WRC to counteract pathogen phagocytosis
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EspG blocks Arf6 signaling to ARNO that activates Arf1
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EspG blocks Arf1 collaboration with Rac1 and WRC activation