Differential neuroimmune markers to the onset of Alzheimer's disease neurodegeneration and dementia: Autoantibodies to Aβ(25–35) oligomers, S100b and neurotransmitters
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- 作者：Marina A. Gruden ; Tatyana B. Davidova ; Mantas Mališ ; auskas ; Robert D.E. Sewell ; Nina I. Voskresenskaya ; Kristina Wilhelm ; Elena I. Elistratova ; Vladimir V. Sherstnev ; Ludmilla A. Morozova-Roche
- 关键词：Alzheimer's disease ; Dementia ; Neuroimmune markers ; Aβ ; (25– ; 35) oligomers ; Protein S100b ; Neurotransmitters
- 刊名：Journal of Neuroimmunology
- 出版年：2007
- 出版时间：May 2007
- 年：2007
- 卷：186
- 期：1-2
- 页码：181-192
- 全文大小：410 K
文摘
Alzheimer's disease (AD) autoimmunity is a focus for dementia prevention. Generated autoantibodies against major etiopathogenic molecular targets as neuroimmune markers of dementia were measured by ELISA in patient sera. Biphasic antibody levels to Aβ(25–35) oligomers, S100b and DA were detected during distinctly diagnosed dementia stages. Aβ(25–35) oligomer autoimmune responses reflected mild to moderate AD dementia, while those to S100b, DA and the S100b concentrations, matched moderate to severe dementia progression. 5-HT antibodies increased during mild dementia and plateaued thereafter. This autoimmunity pattern may be used as a differential biomarker profile in designing AD therapeutic strategies involving early vaccination.