Ruthenium(II)-arene complexes with substituted picolinato ligands: Synthesis, structure, spectroscopic properties and antiproliferative activity

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• 作者：Ivanka Ivanovi膰 ; Katarina K. Jovanovi膰 ; Nevenka Gligorijevi膰 ; Sini拧a Radulovi膰 ; Vladimir B. Arion ; Khalil Salem A.M. Sheweshein ; 沤ivoslav Lj. Te拧i膰 ; Sanja Grguri膰-艩ipka
• 关键词：Ruthenium(II)&ndash ; arene ; Picolinato ligands ; X-ray diffraction ; Anticancer activity
• 刊名：Journal of Organometallic Chemistry
• 出版年：1 January, 2014
• 年：2014
• 卷：749
• 期：Complete
• 页码：343-349
• 全文大小：826 K

文摘

A series of seven new ruthenium(II)-arene complexes of general formula [Ru(畏⁶-p-cymene)(L^1鈭?)Cl], where L^1鈭? are fluoro, chloro, bromo or methyl derivatives of picolinic acid or isoquinoline-3-carboxylic acid has been synthesized and characterized by elemental analysis, IR, ¹H and ¹³C NMR spectroscopy and ESI mass spectrometry. X-ray diffraction studies of two compounds showed the usual piano-stool geometry, with coordination of picolinato ligands through the pyridine nitrogen and the carboxylic group oxygen atom (N/COO^{鈭?/sup> donor set). Cytotoxicity of complexes in聽vitro has been evaluated in three human tumor cell lines: cervix carcinoma (HeLa), melanoma (FemX), lung adenocarcinoma (A549) and one normal cell line (MRC-5). Complex with isoqinoline-3-carboxylic acid as ligand, exhibited significantly lower cytotoxic activity in normal cells (MRC-5) against high activity observed in panel of tumor cells and prominent cell type selectivity among tumor cells.}