Anti-coxsackievirus B3 activity of 2-amino-3-nitropyrazolo[1,5-a]pyrimidines and their analogs
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- 作者：Makarov ; Vadim A. ; Riabova ; Olga B. ; Granik ; Vladimir G. ; Dahse ; Hans-Martin ; Stelzner ; Axel ; et. al.
- 关键词：Nitropyrazolo[1 ; 5-a]pyrimidines ; Antiviral ; Coxsackievirus
- 刊名：Bioorganic and Medicinal Chemistry Letters
- 出版年：2005
- 出版时间：January 3, 2005
- 年：2005
- 卷：15
- 期：1
- 页码：37-39
- 全文大小：257 K
文摘
A novel class of 2-amino-4-nitropyrazolo[1,5-a]pyrimidines has been identified as potent inhibitors of coxsackievirus B3 replication. The synthesis of these compounds is based on the regioselective reaction of 3,5-diamino-5-nitropyrazole with unsymmetrical ??-diketones at catalysis by hydrochloric acid leading to 2-amino-4-nitropyrazolo[1,5-a]pyrimidines as key steps.