Cytotoxic constituents of Achillea clavennae from Montenegro

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• 作者：Snež ; ana Trifunović ; Vlatka Vajs ; Zorica Juranić ; Ž ; eljko Ž ; iž ; ak ; Vele Teš ; ević ; Slobodan Macura and Slobodan Milosavljević
• 关键词：Achillea clavennae ; Asteraceae ; Guaianolides ; Bisabolenes ; Flavonoids ; Cytotoxicity
• 刊名：Phytochemistry
• 出版年：2006
• 出版时间：May 2006
• 年：2006
• 卷：67
• 期：9
• 页码：887-893
• 全文大小：214 K

文摘

Examination of the aerial parts of Achillea clavennae afforded eight guaianolides (1–8), three bisabolenes (9–11), four flavonols (12–15), sesamin (lignan) and isofraxidin (coumarin). The structures of the new compounds (2, 4, 5, 7 and 10) were determined by spectroscopic methods. The antiproliferative action of 2, 8, 9 and 12 were tested to HeLa, K562 and Fem-X human cancer cell lines. Guaianolides 2 (9α-acetoxyartecanin) and 8 (apressin) showed significant cytotoxic effects to all tested lines and inducumenone (9) exhibited a moderate activity. The most active was flavonol centaureidin (12), already known as cytotoxic compound.