Redox-dependent regulation of epidermal growth factor receptor signaling

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• 作者：David E. Heppner ; Albert van der Vliet ; ^{albert.van-der-vliet@uvm.edu" class="auth_mail" title="E-mail the corresponding author}
• 关键词：NADPH oxidase ; NOX/DUOX ; EGFR ; Tyrosine phosphatase ; Tyrosine kinase ; Cysteine oxidation
• 刊名：Redox Biology
• 出版年：2016
• 出版时间：August 2016
• 年：2016
• 卷：8
• 期：Complete
• 页码：24-27
• 全文大小：1038 K

文摘

Tyrosine phosphorylation-dependent cell signaling represents a unique feature of multicellular organisms, and is important in regulation of cell differentiation and specialized cell functions. Multicellular organisms also contain a diverse family of NADPH oxidases (NOXs) that have been closely linked with tyrosine kinase-based cell signaling and regulate tyrosine phosphorylation via reversible oxidation of cysteine residues that are highly conserved within many proteins involved in this signaling pathway. An example of redox-regulated tyrosine kinase signaling involves the epidermal growth factor receptor (EGFR), a widely studied receptor system with diverse functions in normal cell biology as well as pathologies associated with oxidative stress such as cancer. The purpose of this Graphical Redox Review is to highlight recently emerged concepts with respect to NOX-dependent regulation of this important signaling pathway.