O-GlcNAcylation Regulates Cancer Metabolism and Survival Stress Signaling via Regulation of the HIF-1 Pathway
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- 作者：Christina M. Ferrer1 ; Thomas P. Lynch1 ; Valerie L. Sodi1 ; John N. Falcone1 ; Luciana P. Schwab2 ; Danielle L. Peacock2 ; David J. Vocadlo3 ; Tiffany N. Seagroves2 ; Mauricio J. Reginato1 ; mauricio.reginato@drexelmed.edu" class="auth_mail
- 刊名：Molecular Cell
- 出版年：5 June 2014
- 年：2014
- 卷：54
- 期：5
- 页码：820-831
- 全文大小：2757 K
文摘
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Reducing OGT and O-GlcNAcylation in cancer cells decreases cancer glycolysis
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OGT regulates stability of HIF-1伪 via regulation of 伪-ketoglutarate levels
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Reducing OGT levels or activity induces ER stress and apoptosis in cancer cells
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Stable HIF-1伪 mutant or GLUT1 overexpression rescues OGT-mediated phenotypes