Clinical outcome of early glottic carcinoma in Serbia

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• 作者：Jovica Milovanovic^a ; ^b ; Vojko Djukic^a ; ^b ; Aleksandar Milovanovic^a ; ^c ; Ana Jotic^a ; ^b ; ^{anajotic@yahoo.com} ; Bojan Banko^d ; Snezana Jesic^a ; ^b ; Borivoj Babic^e ; ^b ; Aleksandar Trivic^a ; ^b ; Vera Artiko^a ; ^f ; Milorad Petrovic^a ; ^g ; Predrag Stankovic^a ; ^b
• 关键词：Early glottic carcinoma ; Functional results ; Overall-survival ; Disease-specific survival ; Prognostic factors
• 刊名：Auris Nasus Larynx
• 出版年：2013
• 出版时间：August, 2013
• 年：2013
• 卷：40
• 期：4
• 页码：394-399
• 全文大小：242 K

文摘

Objective

Proposed methods for treating early glottic carcinoma are cordectomy through laryngofissure, laser cordectomy, and radiotherapy. The aim of the study was to conduct comprehensive study to evaluate oncological and functional results of different treatment modalities for Tis and T1 glottic carcinoma, identify prognostic factors for the outcome of treatment and decide where we stand in applying worldwide standards of early glottic carcinoma treatment.

Methods

Prospective study was conducted on 221 patients treated with Tis and T1 glottic carcinoma from 1998 to 2003 (72 patients were treated endoscopically with CO₂ laser, 75 patients with cordectomy through laryngofissure and 74 with radiotherapy), with follow-up period from 38 to 107 months. Important demographic and clinical variables were analyzed. Voice quality after the treatment was assessed using multidimensional voice analysis.

Results

Comparing oncological results of three modalities of treatment, there were no significant differences. Functional results of treatment were better after laser cordectomy and primary radiotherapy than following the open cordectomy. Five-year survival rate was almost identical in all three groups of patients, and important prognostic factors for survival were age and histological grade of the tumor.

Conclusion

Considering that the choice of treatment in our country is also greatly influenced by other paramedical factors, such as distance from treatment facility, reliability of follow-up, significant time delay of radiotherapy because of small number of radiology centers and strong patients¡¯ surgeon and treatment preference, we consider endoscopic laser surgery highly efficient and preferred choice of treatment for early glottic carcinoma.