Renal cancer: Oxygen meets metabolism

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• 作者：Volker H. Haase ; ^{volker.haase@vanderbilt.edu}
• 关键词：Renal cell cancer ; VHL tumor suppressor ; Hypoxia-inducible factor ; Oxygen ; Glucose metabolism ; Mitochondria
• 刊名：Experimental Cell Research
• 出版年：2012
• 出版时间：15 May, 2012
• 年：2012
• 卷：318
• 期：9
• 页码：1057-1067
• 全文大小：698 K

文摘

Over the last two decades molecular studies of inherited tumor syndromes that are associated with the development of kidney cancer have led to the identification of genes and biochemical pathways, which play key roles in the malignant transformation of renal epithelial cells. Some of these findings have broad biological impact and extend beyond renal cancer. This review's focus is on the von Hippel-Lindau (VHL)/hypoxia-inducible factor (HIF) oxygen-sensing pathway and its role in physiology, energy metabolism and tumorigenesis.