Activated protein C inhibits the release of macrophage inflammatory protein-1-alpha from THP-1 cells and from human monocytes

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• 作者：Brueckmann ; Martina ; Hoffmann ; Ursula ; de Rossi ; Lothar ; Weiler ; Hans Martin ; Liebe ; Volker ; et. al.
• 关键词：Activated protein C ; Drotrecogin alfa (activated) ; Macrophage inflammatory protein-1-alpha ; Monocyte chemoattractant protein-1 ; Monocytes
• 刊名：Cytokine
• 出版年：2004
• 出版时间：May 7, 2004
• 年：2004
• 卷：26
• 期：3
• 页码：106-113
• 全文大小：292 K

文摘

Several lines of evidence have implicated activated protein C (APC) to be an endogenous inhibitor of the inflammatory septic cascade. APC may exhibit direct anti-inflammatory properties, independent of its antithrombotic effects. Chemokines influence the interaction of monocytes at the endothelium during infection and sepsis and are involved in the molecular events leading to an adverse and lethal outcome of sepsis. Defining regulatory mechanisms on the monocytic release profile of the proinflammatory C-C chemokines macrophage inflammatory protein-1-alpha (MIP-1-α) and monocyte chemoattractant protein-1 (MCP-1) might have therapeutic implications for the treatment of sepsis.