Transient effects of 2,4-dichlorophenoxyacetic acid (2,4-D) exposure on some metabolic and free radical processes in goldfish white muscle

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• 作者：Olga I. Kubrak ; Tetiana M. Atamaniuk ; Viktor V. Husak ; Volodymyr I. Lushchak
• 关键词：2 ; 4-D ; 2 ; 4-dichlorophenoxyacetic acid ; AChE ; acetylcholine esterase ; ALT ; alanine transaminase (alanine aminotransferase) ; AST ; aspartate transaminase (aspartate aminotransferase) ; CP ; carbonyl protein groups ; Total GSH ; total glutathione ; GSSG ; oxidized
• 刊名：Food and Chemical Toxicology
• 出版年：2013
• 出版时间：September, 2013
• 年：2013
• 卷：59
• 期：Complete
• 页码：356-361
• 全文大小：739 K

文摘

This study aims to assess effects of 96 h goldfish exposure to 1, 10 and 100 mg/L of the herbicide, 2,4-dichlorophenoxyacetic acid (2,4-D), on metabolic indices and free radical process markers in white muscle of a commercial fish, the goldfish Carassius auratus L. Most oxidative stress markers and antioxidant enzymes were not affected at 2,4-D fish treatment. 2,4-D fish exposure induced the elevated levels of total (by 46 % and 40 % ) and reduced (by 77 % and 73 % ) glutathione in muscles of goldfish of 10 mg/L 2,4-D and recovery (after 100 mg/L of 2,4-D exposure) groups, respectively. However, in muscles of 100 mg/L 2,4-D exposed goldfish these parameters were depleted (by 47 % and 64 % ). None of investigated parameters of protein and carbohydrate metabolisms changed in white muscles of 2,4-D exposed fish, with exception of lactate dehydrogenase activity, which was slightly (by 11-15 % ) elevated in muscles of goldfish exposed to 10-100 mg/L of 2,4-D, but also recovered. Thus, the short term exposure of goldfish to the selected concentrations of 2,4-D does not substantially affect their white muscle, suggesting the absence of any effect under the environmentally relevant concentrations.