Voltage-Gated P/Q-Type Calcium Channel Antibodies Associated With Cerebellar Degeneration

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• 作者：Mary C. Spiciarich ; MD^a ; ^{mspiciar@montefiore.org" class="auth_mail" title="E-mail the corresponding author} ; Solomon L. Moshé ; MD^a ; ^b ; ^c
• 关键词：paraneoplastic ; cerebellar degeneration ; voltage-gated calcium channel antibodies ; child ; female
• 刊名：Pediatric Neurology
• 出版年：2016
• 出版时间：September 2016
• 年：2016
• 卷：62
• 期：Complete
• 页码：43-46
• 全文大小：397 K

文摘

Paraneoplastic cerebellar degeneration is a rare neurological condition characterized by diffuse cerebellar dysfunction and magnetic resonance imaging evidence of progressive cerebellar atrophy. It has been associated with several autoantibodies and malignancies in adults. To date, only six cases have been described in male children.

Patient Description

We describe an eight-year-old girl with a prodrome of abdominal pain and vomiting followed by acute onset diplopia, dysarthria, dysmetria, and ataxia. She was found to have cerebellar degeneration in association with P/Q-type calcium channel antibodies.

Conclusion

This is the first child with documented paraneoplastic cerebellar degeneration in association with P/Q-type calcium channel antibodies.