Computing rates of Markov models of voltage-gated ion channels by inverting partial differential equations governing the probability density functions of the conducting and non-conducting states
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- 作者：Aslak Tveito ; a ; aslak@simula.no" class="auth_mail" title="E-mail the corresponding author ; Glenn T. Linesa ; Andrew G. Edwardsa ; c ; Andrew McCullochb
- 关键词：Markov models ; Ion channels ; Inversion ; Partial differential equations ; Transmembrane potential
- 刊名：Mathematical Biosciences
- 出版年：2016
- 出版时间：July 2016
- 年：2016
- 卷：277
- 期：Complete
- 页码：126-135
- 全文大小：764 K
文摘
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1">The paper presents a new approach to computing rates of Markov models based on single channel data.
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The paper shows examples of using the new method for models ranging from simple to quite complex Markov models.
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The paper addresses the question of identifiability of Markov models by the method presented in the paper.
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The paper presents an example of a very simple Markov model for which the rates cannot be identified any method.