Oxidation differentially modulates the recombinant voltage-gated Na+ channel α-subunits Nav1.7 and Nav1.8
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- 作者：Friederike Schlü ; ter schlueter.friederike@mh-hannover.de" class="auth_mail" title="E-mail the corresponding author ; Andreas Leffler ; leffler.andreas@mh-hannover.de" class="auth_mail" title="E-mail the corresponding author
- 关键词：TTX ; tetrodotoxin ; Nav ; voltage-gated sodium channel ; TRP ; transient receptor potential ; HEK ; human embryonic kidney ; EGFP ; green fluorescent protein ; DRG ; dorsal root ganglion
- 刊名：Brain Research
- 出版年：2016
- 出版时间：1 October 2016
- 年：2016
- 卷：1648
- 期：part_PA
- 页码：127-135
- 全文大小：2047 K
文摘
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The sensory neuronal Na+ channels Nav1.7 and Nav1.8 are modulated by oxidation.
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10">Oxidation induces non-inactivating persistent currents on Nav1.7 and Nav1.8.
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15">Oxidized Nav1.7 and Nav1.8 generate large ramp currents upon slow depolarizations.
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Slow inactivation of Nav1.7 and Nav1.8 is not modulated by oxidation.