Cathodic adsorptive stripping voltammetry of an anti-emetic agent Granisetron in pharmaceutical formulation and biological matrix

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• 作者：Rajeev Jain ; ^{rajeevjain54@yahoo.co.in} ; Ramkishor Sharma
• 关键词：Granisetron ; Human plasma ; Solid-phase extraction ; Pharmaceutical formulation ; Voltammetry ; Hanging mercury drop electrode
• 刊名：Journal of Pharmaceutical Analysis
• 出版年：2012
• 出版时间：December, 2012
• 年：2012
• 卷：2
• 期：6
• 页码：443-449
• 全文大小：594 K

文摘

Granisetron showed one well-defined reduction peak at Hanging Mercury Drop Electrode (HMDE) in the potential range from ?1.3 to ?1.5 V due to reduction of C=N bond. Solid-phase extraction technique was employed for extraction of Granisetron from spiked human plasma. Granisetron showed peak current enhancement of 4.45 % at square-wave voltammetry and 5.33 % at cyclic voltammetry as compared with the non stripping techniques. The proposed voltammetric method allowed quantification of Granisetron in pharmaceutical formulation over the target concentration range of 50-200 ng/mL with detection limit 13.63 ng/mL, whereas in human plasma 50-225 ng/mL with detection limit 11.75 ng/mL.