Mean platelet volume is decreased in adults with active lupus disease

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• 作者：Guillermo Delgado-Garcí ; a^a ; ^{grdelgadog@gmail.com} ; Dionicio Á ; ngel Galarza-Delgado^a ; ^b ; Iris Colunga-Pedraza^b ; Omar David Borjas-Almaguer^a ; Ilse Mandujano-Cruz^a ; Daniel Benavides-Salgado^a ; Rolando Jacob Martí ; nez-Granados^a ; Alexandro Atilano-Dí ; az^a
• 关键词：Systemic lupus erythematosus ; Mean platelet volume ; Disease activity ; Inflammation ; Biological markers ; Serum albumin
• 刊名：Revista Brasileira de Reumatologia (English Edition)
• 出版年：2016
• 出版时间：November-December 2016
• 年：2016
• 卷：56
• 期：6
• 页码：504-508
• 全文大小：584 K
• 卷排序：56

文摘

Only a few biomarkers are available for assessing disease activity in systemic lupus erythematosus (SLE). Mean platelet volume (MPV) has been recently studied as an inflammatory biomarker. It is currently unclear whether MPV may also play a role as a biomarker of disease activity in adult patients with SLE.ObjectiveWe investigated the association between MPV and disease activity in adult patients with SLE.MethodsIn this retrospective study, we compared two groups of adult patients divided according to disease activity (36 per group). Subjects were age- and gender-matched.ResultsMPV was significantly decreased with respect to those of inactive patients (7.16 ± 1.39 vs. 8.16 ± 1.50, p = 0.005). At a cutoff level of 8.32 fL, MPV has a sensitivity of 86% and a specificity of 41% for the detection of disease activity. A modest positive correlation was found between MPV and albumin (r = 0.407, p = 0.001), which in turn is inversely associated with disease activity.ConclusionsIn summary, MPV is decreased in adult patients with active lupus disease, and positively correlated with albumin, another biomarker of disease activity. Prospective studies are needed to evaluate the prognostic value of this biomarker.