Type II Protein C Deficiency in a 16-Year-Old Girl With Central Retinal Vein Occlusion

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• 作者：Joshua P. Vrabec ; Leonard A. Levin
• 刊名：American Journal of Ophthalmology
• 出版年：2007
• 出版时间：February 2007
• 年：2007
• 卷：143
• 期：2
• 页码：341-342
• 全文大小：367 K

文摘

Purpose

To report a case of central retinal vein occlusion in the setting of type II protein C deficiency, and to describe the appropriate tests for detecting this clotting abnormality.

Design

Observational case report.

Methods

Retrospective review of clinical examination and laboratory findings.

Results

A 16-year-old girl was evaluated for progressive monocular vision loss occurring over a period of one month. Dilated fundus examination and fluorescein angiography revealed the presence of a central retinal vein occlusion. Hypercoagulable work-up demonstrated normal protein C antigen levels, but a marked reduction in protein C function, confirming a type II protein C deficiency.

Conclusions

Central retinal vein occlusion may be associated with type II protein C deficiency. Testing for protein C antigen levels and function is necessary for detection of both type I and type II protein C deficiency.