Selective beneficial cardiometabolic effects of vertical sleeve gastrectomy are predominantly mediated through glucagon-like peptide (GLP-1) in Zucker diabetic fatty rats

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• 作者：Sunil Kumar^a ; Raymond Lau^b ; Thomas Palaia^a ; Christopher Hall^a ; Jenny Lee^a ; Keneth Hall^b ; Collin E. Brathwaite^b ; ^d ; Louis Ragolia^a ; ^d ; ^c ; ^{LRagolia@Winthrop.org}
• 关键词：VSG ; ZDF rats ; Exendin (9&ndash ; 39) ; Myograph ; Lipid profile
• 刊名：Annals of Medicine and Surgery
• 出版年：2016
• 出版时间：December 2016
• 年：2016
• 卷：12
• 期：Complete
• 页码：65-74
• 全文大小：1256 K
• 卷排序：12

文摘

GLP-1 increases post-VSG 30 min after glucose load. Post-VSG GLP-1 secretion is associatged with lower cholesterol and triglycerides. Bile acids and L-PGDS increase post-VSG and are inhibited in the presence of GLP-1 antagonist. Heart rate, blood pressure and myograph profile remain unchanged.