Aging and a long-term diabetes mellitus increase expression of 1 α-hydroxylase and vitamin D receptors in the rat liver
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- 作者：Ana Vuica ; Lejla Ferhatović Hamzić ; Katarina Vukojević ; Milka Jerić ; Livia Puljak ; Ivica Grković ; Natalija Filipović ; natalija.filipovic@mefst.hr" class="auth_mail" title="E-mail the corresponding author
- 关键词：DM ; diabetes mellitus ; VDR ; vitamin D receptor ; 1α-OHase ; 1 α-hydroxylase ; DM1 ; diabetes mellitus type 1 ; RXR ; retinoid X receptors ; STZ ; streptozotocin ; DAPI ; 4&prime ; 6-diamidino-2-phenylindole ; PBS ; phosphate buffer saline ; SD ; standard deviation ; GFAP ; glial fibrillary acidic protein ; Iba1 ; ionized calcium-binding adapter molecule 1 ; VEGF ; vascular endothelial growth factor ; MPO ; myeloperoxidase ; TUNEL ; terminal deoxynucleotidyl transferase-mediated deoxyuridine triphosphate nick end labelin
- 刊名：Experimental Gerontology
- 出版年：2015
- 出版时间：December 2015
- 年：2015
- 卷：72
- 期：Complete
- 页码：167-176
- 全文大小：3099 K
文摘
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1α-Hydroxylase (1α-OHase) is highly expressed by liver monocyte/macrophage system.
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Aging and long-term DM increase the number of 1α-OHase immunoreactive cells in the liver.
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Aging and long-term DM increase the expression of VDR in hepatocytes.
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VDR is strongly expressed in lipid droplets of hepatocytes.