Immunogenicity of a protective whole cell mycobacterial vaccine in HIV-infected adults: A phase III study in Tanzania
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- 作者：Timothy Lahey ; Robert D. Arbeit ; Muhammad Bakari ; C. Robert Horsburgh ; Mecky Matee ; Richard Waddell ; Lillian Mtei ; Jenni M. Vuola ; Kisali Pallangyo ; C. Fordham von Reyn
- 关键词：Tuberculosis ; HIV ; Vaccines ; Interferons ; Cell proliferation
- 刊名：Vaccine
- 出版年：2010
- 出版时间：10 November 2010
- 年：2010
- 卷：28
- 期：48
- 页码：7652-7658
- 全文大小：499 K
文摘
Preventive immunization with whole inactivated Mycobacterium vaccae (MV) confers protection against HIV-associated tuberculosis (TB) in BCG-immunized adults with CD4 counts ≥200 cells/μl. We evaluated the immunogenicity of MV in the 2013 subjects of the phase III DarDarTrial using an interferon gamma (IFN-γ) enzyme linked immunosorbent assay (ELISA), tritiated thymidine lymphocyte proliferation assay (LPA) and an ELISA for antibodies to the TB glycolipid lipoarabinomannan (LAM). MV immunization boosts IFN-γ and LPA responses to MV sonicate, and antibody responses to LAM. Post-immunization immune responses to MV correlated with baseline clinical factors, but the responses did not predict protection from HIV-associated TB.