Magnetic resonance imaging of brain iron in health and disease

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• 作者：Josef Vymazal ; Rodney A. Brooks ; Nicholas Patronas ; Milan Hajek ; Jeff W.M. Bulte ; Giovanni Di Chiro
• 关键词：Brain iron ; Diffusion ; Hallervorden-Spatz disease ; Magnetic resonance imaging ; Parkinson's disease
• 刊名：Journal of the Neurological Sciences
• 出版年：1995
• 出版时间：December 1995
• 年：1995
• 卷：134
• 期：Supplement 1
• 页码：19-26
• 全文大小：692 K

文摘

Brain iron is a major contributor to magnetic resonance imaging (MRI) contrast in normal gray matter, and its role in the pathogenesis of different neurological disorders has also become apparent. Non-heme brain iron is present in the brain mainly in the form of ferritin. The unique magnetic properties of ferritin determine different signal changes on both T1- and T2-weighted images, and the T2 relaxation rates have a linear dependence on applied field strength. This finding is typical for ferric oxyhydroxide cores. The resulting T2-shortening also depends on echo-spacing used in the imaging sequence as well as on the water diffusion coefficient and the size of the ferritin cluster. Quantitation of non-heme brain iron by MRI aids in the diagnosis and monitoring of different neurological diseases.