Maternal care affects EEG properties of spike-wave seizures (including pre- and post ictal periods) in adult WAG/Rij rats with genetic predisposition to absence epilepsy
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- 作者：Evgenia Sitnikova ; jenia-s@mail.ru" class="auth_mail" title="E-mail the corresponding author ; eu.sitnikova@gmail.com" class="auth_mail" title="E-mail the corresponding author ; Elizaveta M. Rutskova li-za-za@yandex.com" class="auth_mail" title="E-mail the corresponding author ; Vladimir V. Raevsky vraevsky@mail.ru" class="auth_mail" title="E-mail the corresponding author
- 关键词：Absence epilepsy ; Spike-wave discharges ; Cross-fostering ; EEG spectral analysis
- 刊名：Brain Research Bulletin
- 出版年：2016
- 出版时间：October 2016
- 年：2016
- 卷：127
- 期：Complete
- 页码：84-91
- 全文大小：1238 K
文摘
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The WAG/Rij rats have genetic predisposition to absence epilepsy.
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Early postnatal experience is capable to modify EEG absence seizures in adulthood.
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WAG/Rij rats fostered to the non-epileptic dams showed fewer and shorter seizures.
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They also showed ∼1.2 Hz increase in frequency of pre- & postictal EEG.
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Absence seizures did not appear in non-epileptic rats cross-fostered to WAG/Rij dams.