Solid organ transplantation in primary mitochondrial disease: Proceed with caution
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- 作者：Sumit Parikh<sup>asup><sup> ; sup><sup>parikhs@ccf.org" class="auth_mail" title="E-mail the corresponding authorsup> ; Amel Karaa<sup>bsup> ; Amy Goldstein<sup>csup> ; Yi S. Ng<sup>dsup> ; Grainne Gorman<sup>dsup> ; Annette Feigenbaum<sup>esup> ; John Christodoulou<sup>fsup> ; Richard Haas<sup>gsup> ; Mark Tarnopolsky<sup>hsup> ; Bruce K. Cohen<sup>isup> ; David Dimmock<sup>jsup> ; Tim Feyma<sup>ksup> ; Mary K. Koenig<sup>lsup> ; Helen Mundy<sup>msup> ; David Niyazov<sup>nsup> ; Russell P. Saneto<sup>osup> ; Mark S. Wainwright<sup>psup> ; Courtney Wusthoff<sup>qsup> ; Robert McFarland<sup>dsup> ; Fernando Scaglia<sup>rsup>
- 关键词：AHS ; Alpers-Huttenlocher Syndrome ; EPC ; epilepsia-partialis-continua ; KSS ; Kearns-Sayre Syndrome ; MELAS ; Mitochondrial Encephalomyopathy ; Lactic Acidosis and Stroke-like episodes ; MIDD ; Maternally Inherited Diabetes and Deafness ; mtDNA ; Mitochondrial DNA
- 刊名：Molecular Genetics and Metabolism
- 出版年：2016
- 出版时间：July 2016
- 年：2016
- 卷：118
- 期：3
- 页码：178-184
- 全文大小：286 K
文摘
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35 patients with primary mitochondrial disease underwent solid-organ transplant
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Survival mostly met outcomes seen in non-mitochondrial disease patients
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Most patients did not have worsening of their disease 90-days post-transplant
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Post-transplant complications were generally treatable
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Many patients did not have a mitochondrial disease diagnosed prior to transplant