Rational design of phenothiazinium derivatives and photoantimicrobial drug discovery
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- 作者：Mark Wainwright<sup>asup><sup> ; sup><sup>mark_wainwright@hotmail.com" class="auth_mail" title="E-mail the corresponding authorsup> ; Andrew McLean<sup>bsup>
- 关键词：Drug resistance ; Methylene blue ; Phenothiazinium ; Photoantimicrobial ; Photosensitiser design
- 刊名：Dyes and Pigments
- 出版年：2017
- 出版时间：January 2017
- 年：2017
- 卷：136
- 期：Complete
- 页码：590-600
- 全文大小：1325 K
文摘
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Functionalisation of phenothiazinium salts increases photodynamic activity.
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Aromatic/aliphatic ring fusion produces longer wavelength absorption.
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Heavy atom inclusion increases singlet oxygen production.
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Increasing cationic character improves photoantimicrobial action.
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Very broad-spectrum activity includes Gram ± bacteria, fungi, viruses and protozoa.