Homeostasis of Microglia in the Adult Brain: Review of Novel Microglia Depletion Systems
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- 作者：Ari Waisman1 ; waisman@uni-mainz.de" class="auth_mail" title="E-mail the corresponding author ; Florent Ginhoux2 ; Melanie Greter3 ; Julia Bruttger1
- 关键词：microglia ; depletion systems ; repopulation ; development ; maintenance ; yolk sac ; erythromyeloid precursors ; macrophages
- 刊名：Trends in Immunology
- 出版年：2015
- 出版时间：October 2015
- 年：2015
- 卷：36
- 期：10
- 页码：625-636
- 全文大小：1832 K
文摘
Microglia are brain macrophages that emerge from early erythro-myeloid precursors in the embryonic yolk sac and migrate to the brain mesenchyme before the blood brain barrier is formed. They seed the brain, and proliferate until they have formed a grid-like distribution in the central nervous system that is maintained throughout lifespan. The mechanisms through which these embryonic-derived cells contribute to microglia homoeostasis at steady state and upon inflammation are still not entirely clear. Here we review recent studies that provided insight into the contribution of embryonically-derived microglia and of adult ‘microglia-like’ cells derived from monocytes during inflammation. We examine different microglia depletion models, and discuss the origin of their rapid repopulation after depletion and outline important areas of future research.