Intravitreal Bevacizumab to Treat Iris Neovascularization and Neovascular Glaucoma Secondary to Ischemic Retinal Diseases in 41 Consecutive Cases

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• 作者：Taku Wakabayashi ; Yusuke Oshima ; Hirokazu Sakaguchi ; Yasushi Ikuno ; Atsuya Miki ; Fumi Gomi ; Yasumasa Otori ; Motohiro Kamei ; Shunji Kusaka ; Yasuo Tano
• 刊名：Ophthalmology
• 出版年：2008
• 出版时间：September 2008
• 年：2008
• 卷：115
• 期：9
• 页码：1571-1580.e3
• 全文大小：623 K

文摘

Purpose

To evaluate the biologic efficacy of intravitreal bevacizumab (IVB) for iris neovascularization (INV) or neovascular glaucoma (NVG) in patients with ischemic retinal disorders.

Design

Retrospective, consecutive, interventional case series.

Participants

Thirty patients (41 eyes) with INV or NVG secondary to ischemic retinal disorders.

Methods

Patients received IVB (1 mg) as the initial treatment for INV or NVG and were followed up for at least 6 months. Ophthalmic evaluations included measurement of visual acuity and intraocular pressure (IOP), a complete ophthalmic examination, and fluorescein angiography. Patients were divided into 3 subgroups: INV without elevated IOP (INV group), NVG with an open angle (O-NVG group), and NVG with angle closure (C-NVG group) for outcomes analysis.

Main Outcome Measures

The controllability of IOP by IVB, incidence of recurrence, and requirement for surgery to treat NVG.

Results

No significant ocular or systemic adverse events developed during follow-up (range, 6–22 months; mean, 13.3 months). The mean IOP levels were 14.7, 31.2, and 44.9 mmHg at baseline in the INV, O-NVG, and C-NVG groups, respectively. In the INV group (9 eyes), the INV regressed or resolved after 1 injection. Iris neovascularization recurred in 4 eyes by 6 months and stabilized after repeated injections without IOP elevation. In the O-NVG group (17 eyes), rapid neovascular regression with successful IOP normalization (≤21 mmHg) occurred in 12 eyes (71 % ) within 1 week after 1 injection. Five (29 % ) of the 17 eyes required surgery by 6 months despite repeated IVB injections, and a total of 7 eyes (41 % ) underwent surgery during follow-up. In the C-NVG group (15 eyes), IVB caused INV resolution but failed to lower the IOP. Fourteen (93 % ) of 15 eyes required surgery by 2 months after initial IVB and achieved IOP stabilization. The mean interval between IVB and surgery was significantly shorter in the C-NVG group than in the O-NVG group (P<0.001).

Conclusions

Intravitreal bevacizumab is well tolerated, effectively stabilized INV activity, and controlled IOP in patients with INV alone and early-stage NVG without angle closure. In advanced NVG, IVB cannot control IOP but may be used adjunctively to improve subsequent surgical results. Further evaluation in controlled randomized studies is warranted.

Financial Disclosure(s)

The authors have no proprietary or commercial interest in any materials discussed in this article.